Ends with the line "we need to fuck"

In post-9/11 New York City, an eclectic group of citizens find their lives entangled, personally, romantically, and sexually, at Shortbus, an underground Brooklyn salon infamous for its blend of art, music, politics, and carnality.

A look at the unusual process used in the making of the film Shortbus (2006) featuring interviews, behind the scenes footage and clips from the feature film. Director John Cameron Mitchell starts with the concept of using real sex in a film with a positive message. The cast of unknowns is selected from homemade audition tapes and then a callback audition workshop. More acting workshops are used to develop the characters and script. The project overcomes a number of obstacles and the rest of the film's development is followed up until its premiere at the Cannes Film Festival.

A man named Seligman finds a fainted wounded woman in an alley and he brings her home. She tells him that her name is Joe and that she is nymphomaniac. Joe tells her life and sexual experiences with hundreds of men since she was a young teenager while Seligman tells about his hobbies, such as fly fishing, reading about Fibonacci numbers or listening to organ music.

The continuation of Joe's sexually dictated life delves into the darker aspects of her adult life and what led to her being in Seligman's care.