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Leonard Shelby is tracking down the man who raped and murdered his wife. The difficulty of locating his wife's killer, however, is compounded by the fact that he suffers from a rare, untreatable form of short-term memory loss. Although he can recall details of life before his accident, Leonard cannot remember what happened fifteen minutes ago, where he's going, or why.

The ghost of a lesbian high-school girl takes revenge on the people who used to bully her. And another young girl finds her old diary detailing her love and rejection when she was alive.