"I am unstoppable"

When a massive, unmanned locomotive roars out of control, the threat is more ominous than just a derailment. The train is laden with toxic chemicals, and an accident would decimate human life and cause an environmental disaster. The only hope of bringing the train to a safe stop is in the hands of veteran engineer Frank Barnes, and young conductor Will Colson, who must risk their lives to save those in the runaway's path. Inspired by true events.

The deranged military and former CIA agent Dean Cage is in a rehab program, trying to forget the traumatic loss of his best friend Scott in Bosnia. When he dates with his girl-friend and Scott's sister, Detective Amy Knight, in a dinning restaurant, he is mistakenly taken as being the CIA agent that is investigating the robbery of the military experiment EX by a man called Sullivan. He is injected with the drug and abducted by the thieves. Amy has six hours to find the also stolen antidote and save Dean's life.