Annie is a young, happy foster kid who's also tough enough to make her way on the streets of New York in 2014. Originally left by her parents as a baby with the promise that they'd be back for her someday, it's been a hard knock life ever since with her mean foster mom Miss Hannigan. But everything's about to change when the hard-nosed tycoon and New York mayoral candidate Will Stacks—advised by his brilliant VP and his shrewd and scheming campaign advisor—makes a thinly-veiled campaign move and takes her in. Stacks believes he's her guardian angel, but Annie's self-assured nature and bright, sun-will-come-out-tomorrow outlook on life just might mean it's the other way around.

An orphan in a facility run by the mean Miss Hannigan, Annie believes that her parents left her there by mistake. When a rich man named Oliver "Daddy" Warbucks decides to let an orphan live at his home to promote his image, Annie is selected. While Annie gets accustomed to living in Warbucks' mansion, she still longs to meet her parents. So Warbucks announces a search for them and a reward, which brings out many frauds.