The villain has two left hands

Three wealthy children's parents are killed in a fire. When they are sent to a distant relative, they find out that he is plotting to kill them and seize their fortune.

Doctor Strange, with the help of mystical allies both old and new, traverses the mind-bending and dangerous alternate realities of the Multiverse to confront a mysterious new adversary.

After his career is destroyed, a brilliant but arrogant surgeon gets a new lease on life when a sorcerer takes him under her wing and trains him to defend the world against evil.

Bob Parr has given up his superhero days to log in time as an insurance adjuster and raise his three children with his formerly heroic wife in suburbia. But when he receives a mysterious assignment, it's time to get back into costume.

Famed concert pianist Stephen Orlac survives a plane crash, but his hands are permanently destroyed. Helpful surgeon Volcheff grafts a pair of new hands on the hapless Orlac. Unfortunately, they're the hands of an executed murderer – useless for a pianist, but quite handy for less delicate work...

A man whose hand has been replaced by a steel one finds that his new hand has the ability to retain enough electricity so he can kill his enemies, which is exactly what he starts to do.

A would-be slasher villain's defining characteristic may be his biggest downfall.