A young Peruvian bear travels to London in search of a new home. Finding himself lost and alone at Paddington Station, he meets the kindly Brown family.

Paddington travels to Peru to visit his beloved Aunt Lucy, who now resides at the Home for Retired Bears. With the Brown Family in tow, a thrilling adventure ensues when a mystery plunges them into an unexpected journey through the Amazon rainforest and up to the mountain peaks of Peru.