Chaos reigns at the natural history museum when night watchman Larry Daley accidentally stirs up an ancient curse, awakening Attila the Hun, an army of gladiators, a Tyrannosaurus rex and other exhibits.

When the magic powers of The Tablet of Ahkmenrah begin to die out, Larry Daley spans the globe, uniting favorite and new characters while embarking on an epic quest to save the magic before it is gone forever.