Gru and Lucy and their girls—Margo, Edith and Agnes—welcome a new member to the Gru family, Gru Jr., who is intent on tormenting his dad. Gru also faces a new nemesis in Maxime Le Mal and his femme fatale girlfriend Valentina, forcing the family to go on the run.

Villainous Gru lives up to his reputation as a despicable, deplorable and downright unlikable guy when he hatches a plan to steal the moon from the sky. But he has a tough time staying on task after three orphans land in his care.