When the Littles adopt Stuart, the mouse, George is initially unwelcoming to his new brother, and the family cat, Snowbell, is even less enthusiastic. Stuart resolves to face these difficulties with as much pluck and courage as he can muster.

Stuart Little: The Animated Series is an American animated television series, loosely based on the E. B. White children's book Stuart Little and more based on the live action movie adaptations. It was produced by Red Wagon Productions and Sony Pictures Television for the HBO Family digital cable television channel, and aired for just one 13-episode season in 2003.