Richard Kimble is falsely convicted of his wife's murder and given the death penalty. En route to death row, Kimble's train derails and crashes, allowing him to escape and begin a cross-country search for the real killer, a "one-armed man". At the same time, Dr. Kimble is hounded by the authorities, most notably dogged by Police Lieutenant Philip Gerard.

Falsely accused of bombing a Los Angeles subway train by “tweet-now, confirm-later” journalism, blue collar worker Mike Ferro must prove his innocence by uncovering the real perpetrator, before the legendary cop heading the investigation can apprehend him.