Man is addicted to bug poison and works with government agencies

Following the events of Captain America: Civil War, Peter Parker, with the help of his mentor Tony Stark, tries to balance his life as an ordinary high school student in Queens, New York City, with fighting crime as his superhero alter ego Spider-Man as a new threat, the Vulture, emerges.

Police lieutenant detective Thomas 'Thom' Randall's steady girl-friend, Dr. Jennifer 'Jen' Allen, is Dr. Aaron Michaels's main assistant on his pharmaceutical firm Bellion's research program to cure the highly contagious, fatal infection Guinin. A convicted murderer, whom Thom arrested, is one of their special drug test subjects, but escapes. The convict and Jen are affected by radioactively altered DNA from an experimental reactor used on mosquitoes which transfer quinine. The convict soon mutates into a mosquito-like monster, which sucks its victims dry. By the time Thom and his junior murder brigade partner Charlie Morrison figure out what happens, Jen starts mutating herself.

A cop on the track of a criminal finds himself in the midst of an unfinished subway tunnel, when his flashlight reveals a startling discovery: a three meter long scorpion-like Bug. With one slice of its massive tail the bug fells the man and devours him. FBI agent Matt Pollack is brought in to investigate, and when forensics reveal the source of the problem, he turns to his friend and entomologist Emily Foster for help.

Ravaged by a debilitating illness, the Toxic Man sets out to stop the cabal of scientists and bureaucrats responsible for his metamorphosis in a surreal stab at vengeance.