Two college students raise a car

To impress a beautiful girl, Harold Kelp, the grandson of professor Julius Kelp, who created a potion to transform his personality, gets his hands on his grandfather's secret elixir and unleashes his destructive alter ego, Jack.

When beautiful Carla Purty joins the university faculty, genetic professor Dr. Sherman Klump grows desperate to whittle his 400-pound frame down to size and win her heart. So, with one swig of his experimental fat-reducing serum, Sherman becomes 'Buddy Love', a fast-talking, pumped-up, plumped down Don Juan.

At a 1962 College, Dean Vernon Wormer is determined to expel the entire Delta Tau Chi Fraternity, but those troublemakers have other plans for him.