Three sisters (Prue, Piper and Phoebe) reunite and unlock their powers to become the Charmed Ones, the most powerful good witches of all time, whose prophesied destiny is to protect innocent lives from evil beings such as demons and warlocks. Each sister possesses unique magical powers that grow and evolve, while they attempt to maintain normal lives in modern day San Francisco.

Set in the fictional college town of Hilltowne, Charmed follows the lives of three sisters, Macy, Mel and Maggie Vera who, after the tragic death of their mother, discover they are three of the most powerful witches of all time.