Professor Phillip Brainard, an absent minded professor, works with his assistant Weebo, trying to create a substance that's a new source of energy and that will save Medfield College where his sweetheart Sara is the president. He has missed his wedding twice, and on the afternoon of his third wedding, Professor Brainard creates flubber, which allows objects to fly through the air.

Beleaguered professor Ned Brainard has already run into a pile of misfortunes with his discovery of the super-elastic substance "Flubber." Now he hopes to have better luck with a gravity-busting derivative he's dubbed "Flubbergas." Ned's experiments, constantly hampered by government obstruction, earn the consternation of his wife, Betsy. But a game-winning modification to a football uniform may help Ned make the case for his fantastic new invention.