Flyswatter

When Seth Brundle makes a huge scientific and technological breakthrough in teleportation, he decides to test it on himself. Unbeknownst to him, a common housefly manages to get inside the device and the two become one.

Test space rockets exploding at liftoff and increased reporting of UFO sightings culminate in a direct attempt by alien survivors of a dead, extra-galactic civilization to invade Earth from impervious flying saucers, using ray-weapons of mass destruction.