animation with female crimeboss who delivers kidnapped children to mad scientist

The adventures of a late-20th-century New York City pizza delivery boy, Philip J. Fry, who, after being unwittingly cryogenically frozen for one thousand years, finds employment at Planet Express, an interplanetary delivery company in the retro-futuristic 31st century.

Fresh off ripping space-time a new one at the end of "Bender's Big Score," the Planet Express crew is back to mend the tear in reality, or (hopefully) at least not make it worse. Beyond the tear, though, lurks a being of inconceivable...tentacularity. What will become of Earth, and indeed, our universe, when faced with the Beast with a Billion Backs?