On a mission deep in the Bolivian jungle, a team of elite commandos finds itself on the receiving end of a lethal betrayal. Now presumed dead, the men join forces with a mysterious operative named Aisha to hunt down their enemy and even the score.

Some bikers are hired by the CIA during the Vietnam War to rescue a captured agent from the clutches of the Red Chinese army. After a round of drinking, fighting, and whoring around, the cycle gang, led by Big Bill Smith, fix up their Yamahas with machine guns, grenades and armor plating, and storm the enemy camp.

Barney Ross leads a band of highly skilled mercenaries including knife enthusiast Lee Christmas, a martial arts expert Yin Yang, heavy weapons specialist Hale Caesar, demolitionist Toll Road, and a loose-cannon sniper Gunner Jensen. When the group is commissioned by the mysterious Mr. Church to assassinate the dictator of a small South American island, Barney and Lee visit the remote locale to scout out their opposition and discover the true nature of the conflict engulfing the city.

Barney, Christmas and the rest of the team comes face-to-face with Conrad Stonebanks, who years ago co-founded The Expendables with Barney. Stonebanks subsequently became a ruthless arms trader and someone who Barney was forced to kill… or so he thought. Stonebanks, who eluded death once before, now is making it his mission to end The Expendables -- but Barney has other plans. Barney decides that he has to fight old blood with new blood, and brings in a new era of Expendables team members, recruiting individuals who are younger, faster and more tech-savvy. The latest mission becomes a clash of classic old-school style versus high-tech expertise in the Expendables’ most personal battle yet.