A drama about a multi-generational family of cops dedicated to New York City law enforcement. Frank Reagan is the New York Police Commissioner and heads both the police force and the Reagan brood. He runs his department as diplomatically as he runs his family, even when dealing with the politics that plagued his unapologetically bold father, Henry, during his stint as Chief.

UFOs appear on Earth, and people who actually see them suddenly find that their blood has turned blue. Soon panic and hysteria result in the new "blue-bloods" being persecuted by the rest of mankind, and eventually certain all-too-familiar measures begin to be taken against them.