Aging publisher Will Randall is at the end of his rope when a younger co-worker snatches his job out from under his nose. But after being bitten by a wolf, Will suddenly finds himself full of youthful vigor. As he struggles to regain his position, he becomes enthralled with Laura Alden, his former boss's daughter. And, as increasingly animal-like urges begin to overwhelm him, Randall worries that he may be turning into the creature that bit him.

Jacob, a man who believes he is a wolf trapped in a human body, is sent to a clinic by his family where he is forced to undergo increasingly extreme forms of "curative" therapies at the hands of The Zookeeper. Jacob’s only solace is the enigmatic Wildcat, with whom he roams the hospital in the dead of night. The two form an improbable friendship that develops into infatuation.