Flying at 40,000 feet in a state-of-the art aircraft that she helped design, Kyle Pratt's 6-year-old daughter Julia vanishes without a trace. Or did she? No one on the plane believes Julia was ever onboard. And now Kyle, desperate and alone, can only count on her own wits to unravel the mystery and save her daughter.

Flight 7500 departs Los Angeles International Airport bound for Tokyo. As the overnight flight makes its way over the Pacific Ocean during its ten-hour course, the passengers encounter what appears to be a supernatural force in the cabin.