Would you be willing to walk away from everyone and everything you've ever known in exchange for your safety? This is the question facing career criminal Bobby "Bats" Batton (Tom Sizemore); on the outs with the mob and facing prosecution for a number of serious crimes, Batton is offered a deal by the FBI in which he will be given immunity in exchange for testifying against his former partners. However, Batton will have to join the Federal Witness Protection Program, which means that he, his wife, and his children will never again see their friends and family.

For years, mild-mannered Wall Street banker George Needleman has meandered through life oblivious to his family's dysfunction and his company's malfeasance, but he's forced to wake up when he learns that he's been framed in a mob-backed Ponzi scheme. Placed under federal protection, George and his family are shipped down South to Madea's house, where the no-nonsense matriarch whips them all into shape using her special brand of tough love.

Earl Stone, a man in his eighties, is broke, alone, and facing foreclosure of his business when he is offered a job that simply requires him to drive. Easy enough, but, unbeknownst to Earl, he's just signed on as a drug courier for a Mexican cartel. He does so well that his cargo increases exponentially, and Earl hit the radar of hard-charging DEA agent Colin Bates.

In 1983, a naive man is detained by Australian Federal Police with lethal narcotics hidden in his stomach. After being apprehended, ‘The Mule’ makes a desperate choice... to defy his bodily functions and withhold the evidence – literally.