Earl Stone, a man in his eighties, is broke, alone, and facing foreclosure of his business when he is offered a job that simply requires him to drive. Easy enough, but, unbeknownst to Earl, he's just signed on as a drug courier for a Mexican cartel. He does so well that his cargo increases exponentially, and Earl hit the radar of hard-charging DEA agent Colin Bates.

In 1983, a naive man is detained by Australian Federal Police with lethal narcotics hidden in his stomach. After being apprehended, ‘The Mule’ makes a desperate choice... to defy his bodily functions and withhold the evidence – literally.