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Morioh, 1999—a normally quiet and peaceful town has recently become a hotbed of strange activity. Jōtarō Kūjō, now a marine biologist, heads to the mysterious town to meet Jōsuke Higashikata. While the two may seem like strangers at first, Jōsuke is actually the illegitimate child of Jōtarō's grandfather, Joseph Joestar. When they meet, Jōtarō realizes that he may have more in common with Jōsuke than just a blood relation. Along with the mild-mannered Kōichi Hirose and the boisterous Okuyasu Nijimura, the group dedicates themselves to investigating recent disappearances and other suspicious occurrences within Morioh. Aided by the power of Stands, the four men will encounter danger at every street corner, as it is up to them to unravel the town's secrets, before another occurs.

Jotaro Kujo is a popular high school student – at least until that day when he thinks he is possessed by a ghost, which is why he locks himself up. During a fight between his grandfather and his grandfather’s friend Muhammad Abdul, he notices that the ghost is his “Stand”, named "Star Platinium", his fighting aura. Later, his mother also gets such a “Stand” and thus falls ill. Jotaro learns that a man named Dio Brando, who was defeated by Jotaro’s great-great-grandfather a hundred years ago, is to blame. He joins his grandfather and Abdul to destroy Dio once and for all.